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Title   사이클로포스파마이드와 방사선 병용 요법시 종양의 크기가 치료 효과에 미치는 영향에 관한 연구 ( Influence of Tumor Size on Chemosensitivity of FSa 2 in Combination of Cyclophosphamide and Radiation )
Publicationinfo   1992 Jan; 024(01): 109-125.
Key_word   Cyclophosphamide, Radiation, Tumor control, Tumor size
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Abstract   The sensitivity of tumor to chemotherapeutic agent depends on tumor size, as has been reported previously by several authors. To estimate the difference in the effect of combination of chemotherapy and radiation therapy along the tumor size, cyclophosphamide and radiation (under clamp hypoxia) was given to 3 day old tumors after transplantation of 1,000 cells(micro- scopic tumors)and 6 mm tumors(gross tumors) of FSa II growing in the leg muscle of C3Hf/Sed mice. TCD50/120 was 48.5(95% CI: 46.5-50.7) Gy and 81.7(95% CI: 77.7-86.0) Gy for 1,000 cell tumors and 6 mm tumors, respectively. When combined with cyclophosphamide, TCD/iwas reduced to 31.0(95% CI: 27.4-35.1)Gy and 75.5(95% CI: 71.6-79.5)Gy, respectively. The estimated dose modification factor was 1.56 for IO(3)cells and 1,08 for 6 mm tumors. Dose reduction was 17.5 and 6.2Gy and these corresponds to 1.40 and 0.49 log cell kill(estimated from Do) for 10(3) cell tumors and 6 mm tumors, respectively. As a result, the effect of cyclophosphamide given prior to irradiation was 2.8 times more effective in 10(3) cell tumors than 6 mm tumors.
저 자   정웅기(Woong Ki Chung),정현대(Hyon De Chung),하성환(Sung Whan Ha),박찬일(Charn Il Park)